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Study of terpene biosynthetic pathways in medicinal plants based on big data analysis

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Sep 23, 2025

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Tetko, I. V., Engkvist, O., & Chen, H. (2016). Does ‘Big Data’exist in medicinal chemistry, and if so, how can it be harnessed?. Future medicinal chemistry, 8(15), 1801-1806. Tetko I. V. Engkvist O. Chen H. ( 2016 ). Does ‘Big Data’exist in medicinal chemistry, and if so, how can it be harnessed? . Future medicinal chemistry , 8 ( 15 ), 1801 - 1806 . Search in Google Scholar

Huang, W., Wang, Y., Tian, W., Cui, X., Tu, P., Li, J., … & Liu, X. (2022). Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants. Antibiotics, 11(10), 1380. Huang W. Wang Y. Tian W. Cui X. Tu P. Li J. Liu X. ( 2022 ). Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants . Antibiotics , 11 ( 10 ), 1380 . Search in Google Scholar

Zhao, Y. J., Cheng, Q. Q., Su, P., Chen, X., Wang, X. J., Gao, W., & Huang, L. Q. (2014). Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants. Applied microbiology and biotechnology, 98, 2371-2383. Zhao Y. J. Cheng Q. Q. Su P. Chen X. Wang X. J. Gao W. Huang L. Q. ( 2014 ). Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants . Applied microbiology and biotechnology , 98 , 2371 - 2383 . Search in Google Scholar

Zwenger, S., & Basu, C. (2008). Plant terpenoids: applications and future potentials. Biotechnology and Molecular Biology Reviews, 3(1), 1. Zwenger S. Basu C. ( 2008 ). Plant terpenoids: applications and future potentials . Biotechnology and Molecular Biology Reviews , 3 ( 1 ), 1 . Search in Google Scholar

Lu, Y. A. O., Jun, L. U., Juan, W. A. N. G., & Wen-Yuan, G. A. O. (2020). Advances in biosynthesis of triterpenoid saponins in medicinal plants. Chinese journal of natural medicines, 18(6), 417-424. Lu Y. A. O. Jun L. U. Juan W. A. N. G. Wen-Yuan G. A. O. ( 2020 ). Advances in biosynthesis of triterpenoid saponins in medicinal plants . Chinese journal of natural medicines , 18 ( 6 ), 417 - 424 . Search in Google Scholar

Wang, Q., Zhao, X., Jiang, Y., Jin, B., & Wang, L. (2023). Functions of Representative Terpenoids and Their Biosynthesis Mechanisms in Medicinal Plants. Biomolecules, 13(12), 1725. Wang Q. Zhao X. Jiang Y. Jin B. Wang L. ( 2023 ). Functions of Representative Terpenoids and Their Biosynthesis Mechanisms in Medicinal Plants . Biomolecules , 13 ( 12 ), 1725 . Search in Google Scholar

Bergman, M. E., Davis, B., & Phillips, M. A. (2019). Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action. Molecules, 24(21), 3961. Bergman M. E. Davis B. Phillips M. A. ( 2019 ). Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action . Molecules , 24 ( 21 ), 3961 . Search in Google Scholar

Hu, Z., Liu, X., Tian, M., Ma, Y., Jin, B., Gao, W., … & Huang, L. (2021). Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants. Medicinal Research Reviews, 41(6), 2971-2997. Hu Z. Liu X. Tian M. Ma Y. Jin B. Gao W. Huang L. ( 2021 ). Recent progress and new perspectives for diterpenoid biosynthesis in medicinal plants . Medicinal Research Reviews , 41 ( 6 ), 2971 - 2997 . Search in Google Scholar

Lu, X., Tang, K., & Li, P. (2016). Plant metabolic engineering strategies for the production of pharmaceutical terpenoids. Frontiers in Plant Science, 7, 1647. Lu X. Tang K. Li P. ( 2016 ). Plant metabolic engineering strategies for the production of pharmaceutical terpenoids . Frontiers in Plant Science , 7 , 1647 . Search in Google Scholar

Sabzehzari, M., & Naghavi, M. R. (2019). Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants. Gene, 682, 13-24. Sabzehzari M. Naghavi M. R. ( 2019 ). Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants . Gene , 682 , 13 - 24 . Search in Google Scholar

Huang, Y., Xie, F. J., Cao, X., & Li, M. Y. (2021). Research progress in biosynthesis and regulation of plant terpenoids. Biotechnology & Biotechnological Equipment, 35(1), 1799-1808. Huang Y. Xie F. J. Cao X. Li M. Y. ( 2021 ). Research progress in biosynthesis and regulation of plant terpenoids . Biotechnology & Biotechnological Equipment , 35 ( 1 ), 1799 - 1808 . Search in Google Scholar

Wang, M., Qiu, X., Pan, X., & Li, C. (2021). Transcriptional factor-mediated regulation of active component biosynthesis in medicinal plants. Current Pharmaceutical Biotechnology, 22(6), 848-866. Wang M. Qiu X. Pan X. Li C. ( 2021 ). Transcriptional factor-mediated regulation of active component biosynthesis in medicinal plants . Current Pharmaceutical Biotechnology , 22 ( 6 ), 848 - 866 . Search in Google Scholar

Lu, X., Huang, L., Scheller, H. V., & Keasling, J. D. (2023). Medicinal terpenoid UDP-glycosyltransferases in plants: recent advances and research strategies. Journal of Experimental Botany, 74(5), 1343-1357. Lu X. Huang L. Scheller H. V. Keasling J. D. ( 2023 ). Medicinal terpenoid UDP-glycosyltransferases in plants: recent advances and research strategies . Journal of Experimental Botany , 74 ( 5 ), 1343 - 1357 . Search in Google Scholar

Abdallah, I. I., & Quax, W. J. (2017, September). A Glimpse into the Biosynthesis of Terpenoids. In International Conference on Natural Resources and Life Sciences (NRLS-2016) (pp. 81-98). KnE Life Sciences. Abdallah I. I. Quax W. J. ( 2017 , September ). A Glimpse into the Biosynthesis of Terpenoids . In International Conference on Natural Resources and Life Sciences (NRLS-2016) (pp. 81 - 98 ). KnE Life Sciences . Search in Google Scholar

Guo, M., Lv, H., Chen, H., Dong, S., Zhang, J., Liu, W., … & Luo, H. (2024). Strategies on biosynthesis and production of bioactive compounds in medicinal plants. Chinese Herbal Medicines, 16(1), 13-26. Guo M. Lv H. Chen H. Dong S. Zhang J. Liu W. Luo H. ( 2024 ). Strategies on biosynthesis and production of bioactive compounds in medicinal plants . Chinese Herbal Medicines , 16 ( 1 ), 13 - 26 . Search in Google Scholar

Tetko, I. V., Engkvist, O., Koch, U., Reymond, J. L., & Chen, H. (2016). BIGCHEM: challenges and opportunities for big data analysis in chemistry. Molecular informatics, 35(11-12), 615-621. Tetko I. V. Engkvist O. Koch U. Reymond J. L. Chen H. ( 2016 ). BIGCHEM: challenges and opportunities for big data analysis in chemistry . Molecular informatics , 35 ( 11-12 ), 615 - 621 . Search in Google Scholar

Lusher, S. J., McGuire, R., van Schaik, R. C., Nicholson, C. D., & de Vlieg, J. (2014). Data-driven medicinal chemistry in the era of big data. Drug discovery today, 19(7), 859-868. Lusher S. J. McGuire R. van Schaik R. C. Nicholson C. D. de Vlieg J. ( 2014 ). Data-driven medicinal chemistry in the era of big data . Drug discovery today , 19 ( 7 ), 859 - 868 . Search in Google Scholar

Bhattacharjee, A. K. (2023). Pharmacophore-based virtual screening of large compound databases can aid “big data” problems in drug discovery. In Big Data Analytics in Chemoinformatics and Bioinformatics (pp. 231-246). Elsevier. Bhattacharjee A. K. ( 2023 ). Pharmacophore-based virtual screening of large compound databases can aid “big data” problems in drug discovery . In Big Data Analytics in Chemoinformatics and Bioinformatics (pp. 231 - 246 ). Elsevier . Search in Google Scholar

Zeng, T., Hess, Jr, B. A., Zhang, F., & Wu, R. (2022). Bio-inspired chemical space exploration of terpenoids. Briefings in Bioinformatics, 23(5), bbac197. Zeng T. Hess, Jr B. A. Zhang F. Wu R. ( 2022 ). Bio-inspired chemical space exploration of terpenoids . Briefings in Bioinformatics , 23 ( 5 ), bbac197 . Search in Google Scholar

Balkrishna, A., Yadav, P., Yadav, P., Saini, A., Kumar, B., & Arya, V. P. (2024). Big Data Analysis of Medicinal Plants. In Ethnopharmacology and OMICS Advances in Medicinal Plants Volume 2: Revealing the Secrets of Medicinal Plants (pp. 363-382). Singapore: Springer Nature Singapore. Balkrishna A. Yadav P. Yadav P. Saini A. Kumar B. Arya V. P. ( 2024 ). Big Data Analysis of Medicinal Plants . In Ethnopharmacology and OMICS Advances in Medicinal Plants Volume 2: Revealing the Secrets of Medicinal Plants (pp. 363 - 382 ). Singapore: Springer Nature Singapore . Search in Google Scholar

Leferink, N. G., & Scrutton, N. S. (2022). Predictive engineering of class I terpene synthases using experimental and computational approaches. ChemBioChem, 23(5), e202100484. Leferink N. G. Scrutton N. S. ( 2022 ). Predictive engineering of class I terpene synthases using experimental and computational approaches . ChemBioChem , 23 ( 5 ), e202100484 . Search in Google Scholar

Ye, J., Zhang, X., Tan, J., Xu, F., Cheng, S., Chen, Z., … & Liao, Y. (2020). Global identification of Ginkgo biloba microRNAs and insight into their role in metabolism regulatory network of terpene trilactones by high-throughput sequencing and degradome analysis. Industrial Crops and Products, 148, 112289. Ye J. Zhang X. Tan J. Xu F. Cheng S. Chen Z. Liao Y. ( 2020 ). Global identification of Ginkgo biloba microRNAs and insight into their role in metabolism regulatory network of terpene trilactones by high-throughput sequencing and degradome analysis . Industrial Crops and Products , 148 , 112289 . Search in Google Scholar

Zi Hong Peng,Hui Jia,Yan Liang Luo,Li Jun Zhang,Jia Tong Zhou,Yuan Han Xie… & Wei Feng Xu. (2024). Talaroterpenoids A–F: Six New Seco-Terpenoids from the Marine-Derived Fungus Talaromyces aurantiacus. Marine Drugs(10),475-475. Zi Hong Peng Hui Jia Yan Liang Luo Li Jun Zhang Jia Tong Zhou Yuan Han Xie Wei Feng Xu ( 2024 ). Talaroterpenoids A–F: Six New Seco-Terpenoids from the Marine-Derived Fungus Talaromyces aurantiacus . Marine Drugs ( 10 ), 475 - 475 . Search in Google Scholar

Sagarika Das,Monoranjan Goswami,R. N. S. Yadav,Ananta Madhab Baruah & Tanoy Bandyopadhyay. (2024). Methyl jasmonate alters expression of enzymes and metabolites of terpenoid biosynthesis in tea cell culture. Plant Cell, Tissue and Organ Culture (PCTOC)(1),25-25. Sagarika Das Monoranjan Goswami R. N. S. Yada. Ananta Madhab Baruah Tanoy Bandyopadhyay ( 2024 ). Methyl jasmonate alters expression of enzymes and metabolites of terpenoid biosynthesis in tea cell culture . Plant Cell, Tissue and Organ Culture (PCTOC) ( 1 ), 25 - 25 . Search in Google Scholar

Yong Shi,Ke An,ShaoX zhou,XuR. Zhang,QuanC. Kan & Xin Tian. (2024). Integration of single-cell sequencing and bulk transcriptome data develops prognostic markers based on PCLAF+ stem-like tumor cells using artificial neural network in gastric cancer. Heliyon(21),e38662-e38662. Yong Shi Ke An ShaoX zhou XuR. Zhang Quan C. Kan Xin Tian ( 2024 ). Integration of single-cell sequencing and bulk transcriptome data develops prognostic markers based on PCLAF+ stem-like tumor cells using artificial neural network in gastric cancer . Heliyon ( 21 ), e38662 - e38662 . Search in Google Scholar

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